Affiliation:
1. Division of Infectious Diseases Department of Medicine University of Nebraska Medical Center Omaha Nebraska USA
Abstract
AbstractFebrile neutropenia (FN) is common among hematologic malignancy patients, including recipients of hematopoietic cell transplantation (HCT) and cellular therapies such as chimeric antigen receptor (CAR)‐T‐cell therapy. Prompt empiric antibiotic use has been the mainstay for decades but a “one‐size‐fits‐all” approach is no longer broadly accepted, as treatment‐related infectious risk are more understood. Growing antimicrobial resistance is an increasing clinical challenge. Evolving strategies on de‐escalation of broad‐spectrum antibiotics in FN without identified infection are areas of particular interest.