Sentinel lymph node detection with indocyanine green and patent blue dye in cervical cancer: A single‐centre feasibility study

Author:

Preston Marta1ORCID,McBain Rosemary1,Rajadevan Niveditha1,Jones Antonia12,Neesham Deborah1,McNally Orla13

Affiliation:

1. Department of Gynaecology Oncology The Royal Women's Hospital Melbourne Victoria Australia

2. Department of Gynaecology Oncology Mercy Hospital for Women Melbourne Victoria Australia

3. The University of Melbourne Melbourne Victoria Australia

Abstract

BackgroundSentinel lymph node (SLN) dissection has been established as standard of care in many tumours. Its use in early cervical cancer is an area of increasing interest and some studies suggest a high detection rate.AimTo explore feasibility of SLN dissection and establish the patient detection rate in women with early cervical cancer.Materials and MethodsAll patients with early cervical cancer, International Federation of Gynaecology and Obstetrics (FIGO) 2018 Stage 1, of any histology who underwent SLN dissection from January 2017 to March 2023 were included. Patients were eligible if they had pelvic confined disease; no suspicious lymph nodes on pre‐operative imaging or intra‐operatively; tumours <4 cm at the time of surgery and no contra‐indications to surgery. Patients were excluded if there was a known allergy to dye or less than six months follow‐up data.ResultsSixty‐two patients were included in the study and 53% had FIGO stage 1b1 disease. The overall bilateral SLN detection rate was 89%, and the side‐specific rate was 94%. Where indocyanine green (ICG) was used alone, the bilateral detection rate was 87% and the side‐specific rate was 93%. Where ICG was used with patent blue dye (PTB) the bilateral detection rate was 92% and the side‐specific rate was 96%. Where PTB was used alone the bilateral detection rate was 85% and the side‐specific rate was 92%. The node positive rate was 6% (7/124) which included isolated tumour cells in four patients.ConclusionSLN dissection with ICG or PTB is feasible in early‐stage cervical cancer.

Publisher

Wiley

Reference32 articles.

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2. The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients with Cervical Cancer;Cibula D;Int J Gynecol Cancer,2018

3. Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer;Rundle S;Cochrane Database Syst Rev,2017

4. Sentinel node dissection is safe in the treatment of early‐stage vulvar cancer;Zee AG;J Clin Oncol,2008

5. Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer;Nagar H;Cochrane Database Syst Rev,2021

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