Biopsy-proven acute cellular rejection as an efficacy endpoint of randomized trials in liver transplantation: a systematic review and critical appraisal

Author:

Rodríguez-Perálvarez Manuel1,Rico-Juri Jose M.2,Tsochatzis Emmanuel3,Burra Patrizia4,De la Mata Manuel1,Lerut Jan2

Affiliation:

1. Department of Hepatology and Liver Transplantation; Reina Sofía University Hospital; IMIBIC; CIBERehd; Córdoba Spain

2. Starzl Unit of Abdominal Transplantation; Cliniques Universitaires Saint Luc; Université Catholique de Louvain (UCL); Brussels Belgium

3. UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit; Royal Free Hospital and UCL; London UK

4. Multivisceral Transplant Unit Gastroenterology; Padova University Hospital; Padova Italy

Funder

European Association for the Study of the Liver (EASL)

Fresenius Biotech

Publisher

Frontiers Media SA

Subject

Transplantation

Reference112 articles.

1. Liver Transplantation: Prevention and Treatment of Rejection

2. A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers;Thorpe;J Clin Epidemiol,2009

3. Safety and efficacy of steroid-free immunosuppression post-liver transplantation: a randomised phase III trial comparing tacrolimus monotherapy after daclizumab induction versus tacrolimus+MMF dual therapy;Bilbao;J Hepatol,2009

4. A randomized, single-center trial comparing thymoglobulin (TG) induction therapy and delayed initiation of tacrolimus to no induction with immediate initiation of tacrolimus in liver transplant (LT) recipients to assess the impact on renal function;Grant;Am J Transplant,2012

5. Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR);Adam;J Hepatol,2012

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