A randomized double‐blind, placebo‐controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA‐230 during experimental human endotoxaemia-Reference-Cited by-同舟云学术

A randomized double‐blind, placebo‐controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA‐230 during experimental human endotoxaemia

Published:2019-05-23 Issue:7 Volume:85 Page:1559-1571
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Groenendael Roger¹²³,Kox Matthijs¹²,Leijte Guus¹²,Koeneman Bouke¹,Gerretsen Jelle¹²,Eijk Lucas¹²³,Pickkers Peter¹²

Affiliation:

1. Department of Intensive Care MedicineRadboud University Medical Center Nijmegen The Netherlands

2. Radboud Center for Infectious Diseases (RCI)Radboud University Medical Center Nijmegen The Netherlands

3. Department of Anesthesiology, Pain and Palliative MedicineRadboud University Medical Center Nijmegen The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.13941

Reference49 articles.

1. Systemic inflammatory response syndrome (SIRS)

2. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

3. Sepsis in European intensive care units: Results of the SOAP study*

4. Does severe non-infectious SIRS differ from severe sepsis?

5. AKI Associated with Cardiac Surgery

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides;European Journal of Pharmaceutical Sciences;2023-02

2. Transcutaneous vagal nerve simulation to reduce a systemic inflammatory response syndrome and the associated intestinal failure: study protocol of a prospective, two-armed, sham-controlled, double-blinded trial in healthy subjects (the NeuroSIRS-Study);International Journal of Colorectal Disease;2021-10-02

3. CHORIONIC GONADOTROPINE: STRUCTURAL HETEROGENEITY, METABOLIC PATHWAY, FUNCTIONS, OBTAINING AND POSSIBILITIES OF CLINICAL APPLICATION;Biotechnologia Acta;2021-06

4. Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study;Critical Care Medicine;2021-04-15

5. Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo;Frontiers in Medicine;2020-11-05