Affiliation:
1. Division of Cancer Cell Biology, Institute of Medical Science University of Tokyo Tokyo Japan
2. Department of Surgery Jikei University School of Medicine Tokyo Japan
Abstract
AbstractAging is a life phenomenon that occurs in most living organisms and is a major risk factor for many diseases, including cancer. Cellular senescence is a cellular trait induced by various genomic and epigenetic stresses. Senescent cells are characterized by irreversible cell growth arrest and excessive secretion of inflammatory cytokines (senescence‐associated secretory phenotypes, SASP). Chronic tissue microinflammation induced by SASP contributes to the pathogenesis of a variety of age‐related diseases, including cancer. Senolysis is a promising new strategy to selectively eliminate senescent cells in order to suppress chronic inflammation, suggesting its potential use as an anticancer therapy. This review summarizes recent findings on the molecular basis of senescence in cancer cells and senolysis.
Funder
Japan Agency for Medical Research and Development
Japan Science and Technology Agency