Covid‐19 positive donor utilization for heart transplantation: The new frontier for donor pool expansion

Author:

Vaidya Gaurang Nandkishor1ORCID,Anaya Paul1,Ignaszewski Maya1,Kolodziej Andrew1,Malyala Rajasekhar2,Rajagopalan Navin1,Sekela Michael2,Birks Emma1

Affiliation:

1. Department of Cardiovascular Medicine University of Kentucky Lexington Kentucky USA

2. Department of Cardiothoracic Surgery University of Kentucky Lexington Kentucky USA

Abstract

AbstractBackground: Hearts from COVID‐19 positive donors (CPD) are being utilized for heart transplantation by some centers; however, this is in the setting of the lack of guidelines or robust evidence. The paucity of evidence is reflected in the recent Organ Procurement and Transplantation Network (OPTN) communication describing CPD utilization as an “unknown risk.” Methods and Results: We analyzed the UNOS database for adult heart transplants performed between January 2021 to December 2022, and CPD comprised of a significant percentage of donors, being used in >10% of recipients in some UNOS regions. Between July 2022 and December 2022, 7.9% of heart transplants were with CPD, and in the same period Hepatitis C positive donors accounted for 7.1% and donation after circulatory death (DCD) accounted for 10.3%. Conclusion: If the transplant community comes up with a standardized approach and guidance in using CPD hearts, this could provide an effective donor pool expansion strategy.

Publisher

Wiley

Subject

Transplantation

Reference8 articles.

1. Global Impact of the COVID-19 Pandemic on Solid Organ Transplant

2. COVID-19 pandemic and worldwide organ transplantation: a population-based study

3. Organ Procurement and Transplantation Network US Department of Health and Human Services. Summary of current evidence and information‐donor SARS‐CoV‐2 testing & organ recovery from donors with a history of COVID‐19.2022. Available at: Accessed July 28 2022.https://optn.transplant.hrsa.gov/media/kkhnlwah/sars‐cov‐2‐summary‐of‐evidence.pdf

4. Patterns and outcomes of COVID‐19 donor utilization for heart transplant;Vaidya GN;Clinical Transplantation

5. Utilization of COVID-19 positive donors for heart transplantation and associated short-term outcomes

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