NOD1 is required forHelicobacter pyloriinduction of IL-33 responses in gastric epithelial cells

Author:

Tran Le Son1,Tran Darren1,De Paoli Amanda1,D'Costa Kimberley1,Creed Sarah J.2,Ng Garrett Z.34,Le Lena1,Sutton Philip345,Silke J.67,Nachbur U.67,Ferrero Richard L.18ORCID

Affiliation:

1. Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research; Monash University; Clayton Victoria Australia

2. Monash Micro Imaging, The Hudson Institute of Medical Research; Monash University; Clayton Victoria Australia

3. Murdoch Children's Research Institute; The Royal Children's Hospital; Parkville Victoria Australia

4. School of Veterinary and Agricultural Science; The University of Melbourne; Parkville Victoria Australia

5. Department of Paediatrics; The University of Melbourne; Parkville Victoria Australia

6. Division of Cell Signalling and Cell Death; The Walter and Eliza Hall Institute; Parkville Victoria Australia

7. Department of Medical Biology; The University of Melbourne; Parkville Victoria Australia

8. Biomedicine Discovery Institute, Department of Microbiology; Monash University; Clayton Victoria Australia

Funder

National Health and Medical Research Council

Faculty of Medicine, Nursing and Health Sciences, Monash University

Publisher

Hindawi Limited

Subject

Virology,Immunology,Microbiology

Reference46 articles.

1. Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism;Allison;Journal of Immunology,2009

2. Posttranslational modification as a critical determinant of cytoplasmic innate immune recognition;Baker;Physiological Reviews,2017

3. Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(−/−) mice;Berg;The American Journal of Pathology,1998

4. Helicobacter pylori cag pathogenicity island (cagPAI) involved in bacterial internalization and IL-8 induced responses via NOD1- and MyD88-dependent mechanisms in human biliary epithelial cells;Boonyanugomol;PLoS One,2013

5. IL33 is a stomach alarmin that initiates a skewed Th2 response to injury and infection;Buzzelli;Cellular and Molecular Gastroenterology and Hepatology,2015

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