A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27

Author:

Lee Jungnam1,Roberts JoAnn S.2,Atanasova Kalina R.3,Chowdhury Nityananda2,Yilmaz Özlem24ORCID

Affiliation:

1. Division of Pulmonary, Critical Care and Sleep Medicine; University of Florida; Florida USA

2. Department of Oral Health Sciences; Medical University of South Carolina; Charleston South Carolina USA

3. Department of Periodontology; University of Florida; Florida USA

4. Department of Microbiology and Immunology; Medical University of South Carolina; Charleston South Carolina USA

Funder

National Institute of Dental and Craniofacial Research

Publisher

Hindawi Limited

Subject

Virology,Immunology,Microbiology

Reference65 articles.

1. Hsp27 as a therapeutic target in cancers;Acunzo;Current Drug Targets,2014

2. Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes;Adam;Laboratory Investigation,2017

3. Small stress proteins: Chaperones that act as regulators of intracellular redox state and programmed cell death;Arrigo;Biological Chemistry,1998

4. Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels;Arrigo;Antioxidants & Redox Signaling,2005

5. Nucleoside-diphosphate-kinase of P. gingivalis is secreted from epithelial cells in the absence of a leader sequence through a pannexin-1 interactome;Atanasova;Scientific Reports,2016

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