E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells

Author:

Lobos-González Lorena,Aguilar Lorena1,Diaz Jorge1,Diaz Natalia1,Urra Hery1,Torres Vicente A.2,Silva Veronica3,Fitzpatrick Christopher3,Lladser Alvaro4,Hoek Keith S.5,Leyton Lisette1,Quest Andrew F. G.1

Affiliation:

1. Laboratorio de Comunicaciones Celulares; Centro de Estudios Moleculares de la Célula (CEMC); Facultad de Medicina; Universidad de Chile; Santiago; Chile

2. Facultad de Odontologia; Universidad de Chile; Santiago; Chile

3. Andes Biotechnologies; Fundación Ciencia para la Vida; Santiago; Chile

4. Laboratory of Gene Immunotherapy; Fundación Ciencia para la Vida; Santiago; Chile

5. Department of Dermatology; University Hospital of Zurich; Zurich; Switzerland

Publisher

Wiley

Subject

Dermatology,General Biochemistry, Genetics and Molecular Biology,Oncology

Reference52 articles.

1. The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma;Ando;Oncol. Rep.,2007

2. Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment;Augustine;Cancer Res.,2008

3. SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity;Barbachano;Oncogene,2010

4. Caveolin-1 secreting LNCaP cells induce tumor growth of caveolin-1 negative LNCaP cells in vivo;Bartz;Int. J. Cancer,2008

5. Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity;Bender;Cancer Res.,2000

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