Affiliation:
1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China
2. Department of Stomatology First Medical Center of Chinese PLA General Hospital Beijing China
Abstract
AbstractTopical application of tyrosinase inhibitors, such as hydroquinone and arbutin, is the most common clinical treatment for hyperpigmentation. Glabridin (Gla) is a natural isoflavone that inhibits tyrosinase activity, free radical scavenging, and antioxidation. However, its water solubility is poor, and it cannot pass through the human skin barrier alone. Tetrahedral framework nucleic acid (tFNA), a new type of DNA biomaterial, can penetrate cells and tissues and can be used as carriers to deliver small‐molecule drugs, polypeptides, and oligonucleotides. This study aimed to develop a compound drug system using tFNA as the carrier to transport Gla and deliver it through the skin to treat pigmentation. Furthermore, we aimed to explore whether tFNA–Gla can effectively alleviate the hyperpigmentation caused by increased melanin production and determine whether tFNA–Gla exerts substantial synergistic effects during treatment. Our results showed that the developed system successfully treated pigmentation by inhibiting regulatory proteins related to melanin production. Furthermore, our findings showed that the system was effective in treating epidermal and superficial dermal diseases. The tFNA‐based transdermal drug delivery system can thus develop into novel, effective options for non‐invasive drug delivery through the skin barrier.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Sichuan Province Youth Science and Technology Innovation Team
Subject
Cell Biology,General Medicine
Cited by
1 articles.
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