Tumor vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid inhibits platelet activation and thrombosis via inhibition of thromboxane A2 signaling and phosphodiesterase

Author:

Zhang S. H.1,Zhang Y.1,Shen J.2,Zhang S.1,Chen L.1,Gu J.3,Mruk J.S.4,Cheng G.5,Zhu L.2,Kunapuli S. P.6,Ding Z.1

Affiliation:

1. Key Laboratory of Molecular Medicine; Ministry of Education; Department of Biochemistry and Molecular Biology; Fudan University Shanghai Medical College; Shanghai China

2. Cyrus Tang Hematology Center; Soochow University; Suzhou China

3. Key Laboratory of Glycoconjuate Research; Ministry of Public Health and Gene Research Center; Fudan University Shanghai Medical College; Shanghai China

4. Department of Internal Medicine; University of Kansas School of Medicine; Witchita KS USA

5. Thoracic Oncology Research Laboratory; University of Pennsylvania; Philadelphia PA USA

6. Department of Physiology; Sol Sherry Thrombosis Research Center; Temple University School of Medicine; Philadelphia PA USA

Funder

National Natural Science of Foundation of China

Shanghai Municipal Science and Technology Commission

Publisher

Wiley

Subject

Hematology

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