Phase I study of the antiprogrammed cell death‐1 Ab spartalizumab (PDR001) in Japanese patients with advanced malignancies

Author:

Minami Hironobu1ORCID,Doi Toshihiko2,Toyoda Masanori1,Imamura Yoshinori1ORCID,Kiyota Naomi1,Mitsuma Ayako3,Shimokata Tomoya3,Naito Yoichi2ORCID,Matsubara Nobuaki2,Tajima Takeshi4,Tokushige Kota4,Ishihara Kae4,Cameron Scott5,Ando Yuichi3ORCID

Affiliation:

1. Kobe University Graduate School of Medicine and Hospital Kobe Japan

2. National Cancer Center Hospital East Kashiwa Japan

3. Nagoya University Hospital Nagoya Japan

4. Novartis Pharma KK Tokyo Japan

5. Novartis Institutes for BioMedical Research Cambridge MA USA

Funder

Novartis Pharmaceuticals Corporation

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference24 articles.

1. PD-1 and Its Ligands in Tolerance and Immunity

2. The blockade of immune checkpoints in cancer immunotherapy

3. Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

4. PD-1 signaling in primary T cells

5. KEYTRUDA (pembrolizumab).Highlights of Prescribing Information MSD International GmbH (revised 06/2018);2014.https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf. Accessed June 2020.

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