Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space

Author:

Miyata Takashi1,Tajima Hidehiro1,Hirata Miki1,Nakanuma Shin-ichi1,Makino Isamu1,Hayashi Hironori1,Oyama Katsunobu1,Miyashita Tomoharu1,Takamura Hiroyuki1,Ninomiya Itasu1,Fushida Sachio1,Iseki Shoichi2,Harada Shin-ichi3,Wakayama Tomohiko4,Ohta Tetsuo1

Affiliation:

1. Department of Gastroenterological Surgery, Division of Cancer Medicine; Kanazawa University; Kanazawa Ishikawa Japan

2. Department of Histology and Embryology, Division of Cancer Medicine; Kanazawa University; Kanazawa Ishikawa Japan

3. Center for Biomedical Research, Graduate School of Medicine; Kanazawa University; Kanazawa Ishikawa Japan

4. Department of Histology, Faculty of Life Sciences; Kumamoto University; Kumamoto Japan

Publisher

Wiley

Subject

Gastroenterology,Hepatology

Reference49 articles.

1. Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica;Bras;A.M.A. Arch. Pathol.,1954

2. Vascular endothelial growth factor (VEGF) is one of the cytokines causative and predictive of hepatic veno-occlusive disease (VOD) in stem cell transplantation;Iguchi;Bone Marrow Transplant.,2001

3. Hepatic veno-occlusive disease in pediatric stem cell transplantation: impact of pre-emptive antithrombin III replacement and combined antithrombin III/defibrotide therapy;Haussmann;Haematologica,2006

4. Vascular Liver Disease and the Liver Sinusoidal Endothelial Cell

5. A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction;Narita;Ann. Surg.,2009

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