Minocycline added to subcutaneous interferon β-1a in multiple sclerosis: randomized RECYCLINE study

Author:

Sørensen P. S.1,Sellebjerg F.1,Lycke J.2,Färkkilä M.3,Créange A.4,Lund C. G.5,Schluep M.6,Frederiksen J. L.7,Stenager E.8,Pfleger C.9,Garde E.10,Kinnunen E.11,Marhardt K.12,

Affiliation:

1. Danish Multiple Sclerosis Center; Department of Neurology; Rigshospitalet; University of Copenhagen; Copenhagen Denmark

2. Department of Neurology; Sahlgrenska University Hospital; Gothenburg Sweden

3. Department of Neurology; University Central Hospital; Helsinki Finland

4. Service de Neurologie; Hôpital Henri Mondor; Université Paris Est Créteil; Créteil France

5. Department of Neurology; Oslo University Hospital; Oslo Norway

6. Service de Neurologie; Département des Neurosciences Cliniques; Centre Hospitalier Universitaire Vaudois; Lausanne Switzerland

7. Department of Neurology; Glostrup Esbjerg, Sonderborg, and Vejle, and University of Copenhagen; Copenhagen Denmark

8. Department of Neurology; Esbjerg Hospital; Sonderborg Hospital; Vejle Hospital; Odense Denmark

9. Department of Neurology; Aalborg Hospital; Aalborg Denmark

10. Danish Research Centre for Magnetic Resonance; Centre for Functional and Diagnostic Imaging and Research; Hvidovre Hospital; University of Copenhagen; Copenhagen Denmark

11. Department of Neurology; HUS Hyvinkään Hospital; Hyvinkää Finland

12. Merck Serono Global Medical Affairs; Merck GmbH; Vienna Austria

Funder

Biogen Idec

Merck Serono

Teva

Sanofi-Aventis

Novartis

RoFAR/Roche

Genzyme

Scleroseforeningen

Sundhed og Sygdom, Det Frie Forskningsråd

Sixth Framework Programme

EMD Serono

CSL Behring

LFB

GE Neuro

Octopharma

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Reference40 articles.

1. Interferon beta-1b is effective in relapsing−remitting multiple-sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial;Duquette;Neurology,1993

2. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG);Jacobs;Ann Neurol,1996

3. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis;PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group;Lancet,1998

4. High incidence of acute leukaemia in multiple sclerosis patients treated with mitoxantrone: a retrospective multicentre Italian study;Martinelli;Mult Scler,2009

5. Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial;Hartung;Lancet,2002

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