Simvastatin increases temozolomide‐induced cell death by targeting the fusion of autophagosomes and lysosomes

Author:

Shojaei Shahla1234,Koleini Navid56,Samiei Ehsan234,Aghaei Mahmoud17,Cole Laura K.8,Alizadeh Javad1,Islam Md Imamul9,Vosoughi Amir‐reza1,Albokashy Mohammed1,Butterfield Yaron1011,Marzban Hassan1,Xu Fred8,Thliveris James1,Kardami Elissavet15,Hatch Grant M.8,Eftekharpour Eftekhar9,Akbari Mohsen234,Hombach‐Klonisch Sabine1,Klonisch Thomas112,Ghavami Saeid1121314ORCID

Affiliation:

1. Department of Human Anatomy and Cell Science Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg Canada

2. Laboratory for Innovation in Microengineering (LiME) Department of Mechanical Engineering University of Victoria Canada

3. Center for Biomedical Research University of Victoria Canada

4. Center for Advanced Materials and Related Technology (CAMTEC) University of Victoria Canada

5. Institute of Cardiovascular Sciences St‐Boniface Hospital Albrechtsen Research Centre Winnipeg Canada

6. Department of Physiology and Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg Canada

7. Department of Clinical Biochemistry School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences Isfahan Iran

8. Department of Pharmacology & Therapeutics, Center for Research and Treatment of Atherosclerosis Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg Canada

9. Regenerative Medicine Program Spinal Cord Research Centre Department of Physiology and Pathophysiology University of Manitoba Winnipeg Canada

10. Genome Sciences Centre BC Cancer Vancouver Canada

11. Patient Advocate and Research Committee Brain Tumour Foundation of Canada Ottawa Canada

12. Research Institute in Oncology and Hematology CancerCare Manitoba University of Manitoba Winnipeg Canada

13. Biology of Breathing Children Hospital Research Institute of Manitoba Max Rady College of Medicine Rady Faculty of Health Sciences Winnipeg Canada

14. Health Policy Research Center Institute of Health Shiraz University of Medical Sciences Iran

Funder

Natural Sciences and Engineering Research Council of Canada

University of Manitoba

Mitacs

Canadian Institutes of Health Research

Canada Foundation for Innovation

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

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