Computerized planimetry to assess clinical responsiveness in a phase II randomized trial of topical R333 for discoid lupus erythematosus

Author:

Presto J.K.12ORCID,Okon L.G.12,Feng R.3,Wallace D.J.4,Furie R.5,Fiorentino D.6,Werth V.P.12

Affiliation:

1. Corporal Michael J. Crescenz Veterans Affairs Medical Center (Philadelphia); Philadelphia PA U.S.A.

2. Department of Dermatology at the Perelman School of Medicine at the University of Pennsylvania; Pennsylvania PA U.S.A.

3. Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania; Pennsylvania PA U.S.A.

4. Division of Rheumatology; Cedars-Sinai Medical Center; Los Angeles CA U.S.A.

5. Division of Rheumatology; Northwell Health; Great Neck NY U.S.A.

6. Department of Dermatology; Stanford University School of Medicine; Stanford CA U.S.A.

Funder

U.S. Department of Veterans Affairs

Office of Research and Development

Biomedical Laboratory Research and Development, VA Office of Research and Development

Publisher

Wiley

Subject

Dermatology

Reference12 articles.

1. T cell-directed therapies: lessons learned and future prospects;Liu;Nat Immunol,2007

2. A new modality for immunosuppression: targeting the JAK/STAT pathway;O'Shea;Nat Rev Drug Discov,2004

3. Ruxolitinib attenuates cutaneous lupus development in a mouse lupus model;Chan;J Invest Dermatol,2015

4. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice;Deng;Arthritis Rheum,2010

5. Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice;Llop-Guevara;Arthritis Res Ther,2015

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