Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF ‐like conformation of Tau protein-Reference-Cited by-同舟云学术

Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF ‐like conformation of Tau protein

Published:2016-07-12 Issue:5 Volume:15 Page:914-923
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Manassero Giusi¹²³,Guglielmotto Michela¹²,Zamfir Raluca²,Borghi Roberta³,Colombo Laura⁴,Salmona Mario⁴,Perry George⁵,Odetti Patrizio³⁶,Arancio Ottavio⁷,Tamagno Elena¹²,Tabaton Massimo³

Affiliation:

1. Department of Neuroscience University of Torino via Cherasco 15 10126 Torino Italy

2. Neuroscience Institute of Cavalieri Ottolenghi Foundation (NICO) University of Torino Regione Gonzole 1010043 OrbassanoTorino Italy

3. Unit of Geriatric Medicine Department of Internal Medicine and Medical Specialties (DIMI) University of Genova Viale Benedetto XV, 616132 Genova Italy

4. Department of Molecular Biochemistry and Pharmacology IRCCS‐Istituto di Ricerche Farmacologiche ‘Mario Negri’ Via Giuseppe La Masa 19, 20156 Milan Italy

5. College of Sciences The University of Texas at San Antonio One UTSA Circle San Antonio TX 78249 USA

6. IRCCS San Martino‐IST University of Genova Viale Benedetto XV, 616132 Genova Italy

7. Department of Pathology and Cell Biology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University 630 West 168th Street, P&S 12‐420D New York NY 10032 USA

Funder

Ministero della Salute

Compagnia di San Paolo

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12500

Reference45 articles.

1. Hyperphosphorylation induces self-assembly of into tangles of paired helical filaments/straight filaments

2. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity