Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion

Author:

Stearns-Reider Kristen M.12,D'Amore Antonio3,Beezhold Kevin4,Rothrauff Benjamin5,Cavalli Loredana1,Wagner William R.236,Vorp David A.2367,Tsamis Alkiviadis8,Shinde Sunita1,Zhang Changqing1,Barchowsky Aaron4,Rando Thomas A.910,Tuan Rocky S.25,Ambrosio Fabrisia127

Affiliation:

1. Department of Physical Medicine and Rehabilitation; University of Pittsburgh; Kaufmann Medical Building, Suite 201, 3471 Fifth Avenue Pittsburgh PA 15213 USA

2. McGowan Institute for Regenerative Medicine; University of Pittsburgh; 450 Technology Drive, Suite 300 Pittsburgh PA 15219 USA

3. Department of Surgery; University of Pittsburgh; 450 Technology Drive, Suite 300 Pittsburgh PA 15219 USA

4. Department of Environmental and Occupational Health; University of Pittsburgh; 100 Technology Drive, Suite 328 Pittsburgh PA 15219 USA

5. Center for Cellular and Molecular Engineering; Department of Orthopaedic Surgery; University of Pittsburgh; 450 Technology Drive, Bridgeside Point II, Suite 221 Pittsburgh PA 15219 USA

6. Center for Vascular Remodeling and Regeneration; Center for Bioengineering (CNBIO); University of Pittsburgh; 300 Technology Drive, Suite 300 Pittsburgh PA 15219 USA

7. Department of Bioengineering; University of Pittsburgh; 213 Center for Bioengineering, 300 Technology Drive Pittsburgh PA 15219 USA

8. Department of Engineering; University of Leicester; 127 Michael Atiyah Building, University Road Leicester LE1 7RH UK

9. Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences; Stanford University School of Medicine; Stanford CA 94305 USA

10. RR&D Center; VA Palo Alto Health Care System; Palo Alto CA 94304 USA

Funder

National Institutes of Health

National Institute on Aging

National Institute of Environmental Health Sciences

University of Pittsburgh Medical Center Rehabilitation Institute

Publisher

Wiley

Subject

Cell Biology,Aging

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