Genetically-Engineered Antibodies: Tools for the Study of Diverse Properties of the Antibody Molecule
Author:
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1600-065X.1992.tb01522.x/fullpdf
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1. Hidden rheumatoid factors with specificity for native γ globulins
2. Monoclonal IgM rheumatoid factors bind IgG at a discontinuous epitope comprised of amino acid loops from heavy-chain constant-region domains 2 and 3.
3. Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.
4. Complement activation by immunoglobulin does not depend solely on C1q binding
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