A Quantitative Trait Locus Associated With Cognitive Ability in Children-Reference-Cited by-同舟云学术

A Quantitative Trait Locus Associated With Cognitive Ability in Children

Published:1998-05 Issue:3 Volume:9 Page:159-166
ISSN:0956-7976
Container-title:Psychological Science
language:en
Short-container-title:Psychol Sci

Author:

Chorney M.J.¹,Chorney K.¹,Seese N.¹,Owen M.J.²,Daniels J.²,McGuffin P.²,Thompson L.A.³,Detterman D.K.³,Benbow C.⁴,Lubinski D.⁴,Eley T.⁵,Plomin R.⁵

Affiliation:

1. Department of Microbiology and Immunology, Milton S. Hershey Medical Center, Pennsylvania State University

2. Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, United Kingdom

3. Department of Psychology, Case Western Reserve University

4. Department of Psychology, Iowa State University

5. Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom

Abstract

Quantitative trait loci (QTLs) associated with general cognitive ability ( g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high- g group (.303; average IQ = 136, N = 51) than in a control group (.156; average IQ = 103, N = 51). This association was replicated in an extremely-high- g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group ( N = 62) and a high-verbal-ability group ( N = 51) yielded results that were in the same direction but only marginally significant ( p = .06 and .08, respectively).

Publisher

SAGE Publications

Subject

General Psychology

Link

http://journals.sagepub.com/doi/pdf/10.1111/1467-9280.00032

Reference36 articles.

1. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

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4. Some Methods for Strengthening the Common χ 2 Tests

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