Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo-Reference-Cited by-同舟云学术

Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo

Published:2021-06-12 Issue:4 Volume:158 Page:960-979
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J. Neurochem.

Author:

Vecchio Laura M.¹^ORCID,Sullivan Patricia²,Dunn Amy R.³^ORCID,Bermejo Marie Kristel¹,Fu Rong⁴,Masoud Shababa T.¹,Gregersen Emil⁵^ORCID,Urs Nikhil M.⁶^ORCID,Nazari Reza¹,Jensen Poul Henning⁵^ORCID,Ramsey Amy¹^ORCID,Goldstein David S.²^ORCID,Miller Gary W.⁷^ORCID,Salahpour Ali¹

Affiliation:

1. Department of Pharmacology and Toxicology Faculty of Medicine University of Toronto Toronto ON Canada

2. Autonomic Medicine Section Clinical Neurosciences Program Division of Intramural Research National Institute of NeurologicalDisorders and StrokeNational Institutes of Health Bethesda MD USA

3. The Jackson Laboratory. Bar Harbor Maine USA

4. Department of Pharmacology Emory University School of Medicine Atlanta GA USA

5. Danish Research Institute of Translational Neuroscience – DANDRITE Department of Biomedicine Faculty of Health Aarhus University Aarhus C. Denmark

6. Department of Pharmacology and Therapeutics University of Florida Gainsville FL USA

7. Department of Environmental Health Sciences Mailman School of Public Health Columbia University Medical Centre New York NY USA

Funder

Canadian Institutes of Health Research

Lundbeckfonden

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15432

Reference127 articles.

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3. Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and an ortho-Quinone

4. Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

5. Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals

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