Expression and prognostic value of Cripto‐1 in early non‐small cell lung cancer-Reference-Cited by-同舟云学术

Expression and prognostic value of Cripto‐1 in early non‐small cell lung cancer

Published:2023-08 Issue:12 Volume:17 Page:1203-1208
ISSN:1752-6981
Container-title:The Clinical Respiratory Journal
language:en
Short-container-title:Clinical Respiratory J

Author:

Zhong Jian¹,Li Li²³,Zhang Qian²³,Zou Jue⁴,Liu Wei²,Xu Chun Hua²³^ORCID

Affiliation:

1. Department of Thoracic Surgery Affiliated Nanjing Brain Hospital, Nanjing Medical University Nanjing China

2. Department of Respiratory Medicine Affiliated Nanjing Brain Hospital, Nanjing Medical University Nanjing China

3. Clinical Center of Nanjing Respiratory Diseases and Imaging Nanjing China

4. Department of Pathology Affiliated Nanjing Brain Hospital, Nanjing Medical University Nanjing China

Abstract

AbstractObjectiveWe aim to explore the expression of Cripto‐1 (CR‐1) protein in patients with early stage non‐small cell lung cancer (NSCLC).MethodsWe investigated CR‐1 expression status in specimens obtained from 240 patients with resected NSCLC and 30 cases of para‐carcinous normal lung tissues.ResultsCompared with normal lung tissue, the positive expression of CR‐1 protein in NSCLC was significantly increased (p < 0.005). Cox multivariate regression analysis showed that the expression of CR‐1 protein was an independent prognostic factor for early stage NSCLC (p = 0.002).ConclusionDetecting CR‐1 protein can predict the prognosis and recurrence in patients with NSCLC.

Publisher

Wiley

Subject

Genetics (clinical),Pulmonary and Respiratory Medicine,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/crj.13680

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4. Prognostic and Predictive Markers of Benefit from Adjuvant Chemotherapy in Early-Stage Non-small Cell Lung Cancer

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