Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic‐guided prophylaxis

Author:

Valentino L. A.1,Pipe S. W.2,Collins P. W.3,Blanchette V. S.4,Berntorp E.5,Fischer K.6,Ewenstein B. M.7,Oh M.7,Spotts G.7

Affiliation:

1. Baxalta US Inc. Deerfield ILUSA

2. University of Michigan Ann Arbor MI USA

3. School of Medicine Cardiff University Cardiff UK

4. Hospital for Sick Children Toronto ON Canada

5. Lund University Skane University Hospital Malmö Sweden

6. Van Creveldkliniek University Medical Center Utrecht Utrecht the Netherlands

7. Baxter Healthcare Corporation Westlake Village CA USA

Funder

Baxalta US, Inc.

Publisher

Wiley

Subject

Genetics(clinical),Hematology,General Medicine

Reference26 articles.

1. Guidelines for the management of hemophilia

2. National Hemophilia Foundation. MASAC [Medical and Scientific Advisory Council] Recommendation 179.MASAC recommendation concerning prophylaxis (regular administration of clotting factor concentrate to prevent bleeding). Available athttp://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=57&contentid=1007. Accessed November 4 2007.

3. A longitudinal study of orthopaedic outcomes for severe factor-VIII-deficient haemophiliacs

4. Prophylaxis versus Episodic Treatment to Prevent Joint Disease in Boys with Severe Hemophilia

5. A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study)

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