Affiliation:
1. Allergy Center National Center for Child Health and Development Tokyo Japan
2. Biological Science Research, Kao Corporation Tochigi Japan
Abstract
AbstractBackgroundThe molecular pathogenesis of atopic dermatitis (AD), presenting skin barrier dysfunction and abnormal inflammations around 1–2 months, is unreported.ObjectiveWe aimed to examine the molecular pathogenesis of very early‐onset AD by skin surface lipid‐RNA (SSL‐RNA) using a non‐invasive technology in infants aged 1 and 2 months from a prospective cohort.MethodsWe collected sebum by oil‐blotting film of infants aged 1 and 2 months and analysed RNAs in their sebum. We diagnosed AD according to the United Kingdom Working Party's criteria.ResultsInfants with AD aged 1 month showed lower expression of genes related to various lipid metabolism and synthesis, antimicrobial peptides, tight junctions, desmosomes and keratinization. They also had higher expression of several genes involved in Th2‐, Th17‐ and Th22‐type immune responses and lower expression of negative regulators of inflammation. In addition, gene expressions related to innate immunity were higher in AD infants. Infants aged 1 month with neonatal acne and diagnosed with AD aged 2 months already had gene expression patterns similar to AD aged 1 month in terms of redox, lipid synthesis, metabolism and barrier‐related gene expression.ConclusionWe identified molecular changes in barrier function and inflammatory markers that characterize the pathophysiology of AD in infants aged 1 month. We also revealed that neonatal acne at 1 month could predict the subsequent development of AD by sebum transcriptome data.
Funder
Japan Agency for Medical Research and Development
Kao Corporation
Subject
Infectious Diseases,Dermatology
Cited by
2 articles.
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