Affiliation:
1. Vancouver Prostate Centre, Department of Urologic Sciences University of British Columbia Vancouver BC Canada
2. Department of Urology University Hospital Southampton Hampshire UK
3. Department of Anesthesia University of British Columbia Vancouver BC Canada
Abstract
ObjectiveTo evaluate whether rectus sheath catheter (RSC) insertion may be an alternative to thoracic epidural (TE).Patients and MethodsIn a non‐blinded, single‐centre, non‐inferiority study, patients undergoing open radical cystectomy were randomized 1:1 to receive either a TE or surgically placed RSC. The primary endpoint was cumulative opiate use (median oral morphine equivalent [OME]) in the first 72 h postoperatively. Secondary outcomes included visual analogue scale pain scores, measures of postoperative recovery including mobility and time to regular diet, and complications.ResultsNinety‐seven patients were randomized (51 TE, 46 RSC). The median OME was 103 (77.5–132.5) mg in the TE arm and 161.75 (117.5–187.5) mg in the RSC arm. A Mann–Whitney U‐test confirmed non‐inferiority of RSC to TE at a threshold of 15 mg OME (P = 0.002). When comparing pain scores for the first three postoperative days, an early difference was observed that favoured the TE group during post‐anaesthesia care unit stay, which was lost after postoperative day 1. Patient satisfaction with analgesia on the third postoperative day was similar in the two arms (P = 0.47). There were no statistically significant differences between arms with respect to the other secondary outcomes.ConclusionsThe outcomes from this prospective randomized trial demonstrated non‐inferiority of RSC insertion compared to TE with respect to 72‐h opiate use. Patient satisfaction with pain control on postoperative day 3 was the same for each group.