Donor-derived CD19-targeted T cell infusion induces minimal residual disease-negative remission in relapsed B-cell acute lymphoblastic leukaemia with no response to donor lymphocyte infusions after haploidentical haematopoietic stem cell transplantation

Author:

Chen Yuhong1,Cheng Yifei1,Suo Pan1,Yan Chenhua1,Wang Yu1,Chen Yao1,Han Wei1,Xu Lanping1,Zhang Xiaohui1ORCID,Liu Kaiyan1,Chang Lungji2,Xiao Lei3,Huang Xiaojun1ORCID

Affiliation:

1. Peking University People's Hospital; Peking University Institute of Haematology; Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation; Collaborative Innovation Centre of Haematology; Peking University; Beijing China

2. Shenzhen Geno-Immune Medical Institute; Beijing China

3. Innovative Cellular Therapeutics Co. Ltd; Beijing China

Funder

Foundation for Innovative Research Groups of the National Natural Science Foundation of China

Publisher

Wiley

Subject

Hematology

Reference30 articles.

1. Toxicities of chimeric antigen receptor T cells: recognition and management;Brudno;Blood,2016

2. Allogeneic T cells that express an anti-CD19 chimeric antigen receptor induce remission of B-cell malignancies that progress after allogeneic hematopoietic stem-cell transplantation without causing graft-versus-host disease;Brudno;Journal of Clinical Oncology,2016

3. [The efficacy and safety of second allogeneic hematopoietic stem cell transplantation for post-transplant hematologic malignancies relapse];Chen;Zhonghua Nei Ke Za Zhi,2011

4. Chimeric antigen receptors T cells as second line therapy for acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation: high remission rate without causing graft versus host disease;Chen;Chinese Journal of Organ Transplantation,2016

5. T-cell and natural killer cell therapies for hematologic malignancies after hematopoietic stem cell transplantation: enhancing the graft-versus-leukemia effect;Cruz;Haematologica,2015

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