Racial disparities in the incidence and survival outcomes in diffuse large B‐cell lymphoma in adolescents and young adults

Author:

Wasifuddin Mustafa1ORCID,Ilerhunmwuwa Nosakhare Paul1,Becerra Henry1,Hakobyan Narek1,Shrestha Neharika1,Uche Ifeanyi Nnamdi1,Lin Htet1,Abowali Hesham2ORCID,Zheng Jin2,Yadav Ruchi2,Pokhrel Akriti2,Enayati Ladan2,Hare Mitchell1,Hehr Rohan1,Kozii Khrystyna1,Gibadullin Bulat1,Avezbakiyev Boris2,Wang Jen‐Chin2ORCID

Affiliation:

1. Department of Medicine Brookdale University Hospital and Medical Center Brooklyn New York USA

2. Division of Hematology/Oncology Brookdale University Hospital and Medical Center Brooklyn New York USA

Abstract

AbstractDiffuse large B‐cell Lymphoma (DLBCL) is an aggressive subtype of non‐Hodgkin lymphoma (NHL). The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA). There is paucity of data in the literature on racial and ethnic disparities in the incidence and survival outcomes of DLBCL in the AYA group. The objective of our study is to demonstrate the disparities in these outcomes. Utilizing SEER, we obtained data on patient demographics, incidence, and survival from 2000 to 2020. We observed statistically significant reduced incidence of DLBCL in all racial groups, except the non‐Hispanic Asian and Pacific Islander group (NHAPI). The non‐Hispanic Black group (NHB) had one of the lowest survival despite showing the largest decrease in incidence in DLBCL. The differences in the survival could be secondary to socioeconomic factors, however other reasons need to be explored. The increased incidence among the NHAPI group mirrors that of large population‐based studies in East Asian countries, however, underlying reasons have not been elucidated.

Publisher

Wiley

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