Promoter region variant C‐824T in the TH gene modulates the subjective effects of cocaine

Abstract

AbstractBackground and ObjectivesThis study examined how a promoter variant of TH (rs10770141) affects subjective effects of cocaine in 65 nontreatment‐seeking individuals with cocaine dependence.MethodsParticipants received cocaine/saline intravenously, and TH genotypes were evaluated.ResultsHomozygous individuals for the minor T allele reported greater “good” and “bad” subjective effects to cocaine than those with the major C allele.Discussion and ConclusionsTH rs10770141 modulates subjective effects of cocaine in participants with cocaine dependence.Scientific SignificanceThese results are among the first to indicate that homozygosity of the T allele of rs10770141 modulates greater sensitivity to cocaine.