Pharmacokinetic and pharmacodynamic simulation for the quantitative risk assessment of linezolid‐associated thrombocytopenia
Author:
Affiliation:
1. Department of Pharmacy Shimane University Hospital Izumo Japan
2. Department of Clinical Pharmacotherapy Hiroshima University Hiroshima Japan
3. School of Pharmacy at Fukuoka International University of Health and Welfare Fukuoka Japan
Publisher
Hindawi Limited
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcpt.13747
Reference36 articles.
1. "Treatment Guidelines for MRSA Infections ‐ 2019 Revision" by The Japanese Society for Chemotherapy and The Japanese Society for Infectious Diseases.
2. Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects;Slatter JG;Drug Metab Dispos,2001
3. Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction
4. Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction
5. High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia
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3. Risk factors for thrombocytopenia in patients receiving linezolid therapy: a systematic review and meta-analysis;European Journal of Clinical Pharmacology;2023-08-14
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