Affiliation:
1. Yanbian University Hospital Yanji Jilin Province China
2. Department of Physiology & Biomedical Sciences Ischemic/hypoxic Disease Institute, Seoul National University, College of Medicine Seoul Korea
3. Division of Cardiovascular Institute University of Manchester Manchester UK
Abstract
AbstractBackgroundImpaired microcirculation in acute coronary syndrome (ACS) patients manifests inadequate recovery and adverse clinical outcome. Here, we analyzed correlations between peripheral microcirculation and heart function in ACS patients.MethodsOpisthenar microvessel area (OMA) were measured with optical coherence tomography angiography (OCTA), cardiac functional indexes (echocardiograph) were assessed 48–72 h after therapeutic interventions.ResultsResults showed that OMA normalized with heart rate (OMA‐HR) were significantly greater in ACS patients with percutaneous intervention (ACS‐PCI, n = 25, stenosis >80%) compared to those with pharmacological intervention (ACS‐PI, n = 23, stenosis <50%, p = .02). Ejection fraction (EF) and fractional shortening (FS), which were not different between two groups, showed negative correlations with OMA‐HR in ACS‐PCI (EF: r = −0.512, p = .009; FS: r = −0.594, p = .002). Cardiac output (CO) inversely correlated with OMA‐HR in both groups (r = −0.697, p < .0001; r = −0.527, p = .01). Neutrophil to lymphocyte ratio (NLR) on admission was greater in ACS‐PCI group. NLR, which was negatively associated with EF or FS, was positively associated with OMA‐HR in all patients. The area under the curve (AUC) for OMA‐HR was 0.683 (specificity 0.696 and sensitivity 0.72, p = .02). OMA‐HR at >376.5 μm2 predicts reduced FS and CO (p = .002, p = .005, respectively). Summary OMA‐HR predicts inadequate recovery of the heart in severe ACS patients post‐PCI.
Funder
National Natural Science Foundation of China
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Molecular Biology,Physiology