Affiliation:
1. Department of Dermatology and Venereology, Faculty of Medicine Tanta University Tanta Egypt
2. Department of Pathology, Faculty of Medicine Tanta University Tanta Egypt
Abstract
AbstractThere are several reported cases of Wolf's isotopic response, including infections, cancers, inflammatory and immune‐related disorders. It is interesting that the majority of these occurred after herpes zoster (HZ) had healed. In this article, we describe an unusual case of adult mastocytosis/telangiectasia macularis eruptiva perstans (TMEP) at the location of recovered HZ. Given that adult mastocytosis is thought to be caused by dysregulation of the mast cell growth factor receptor, the c‐Kit proto‐oncogene (CD117), and the fact that the varicella zoster virus‐infected cutaneous lesions contain CD117‐positive mast cells (CD117+MCs), we hypothesize that CD117+ MCs may be in charge of the local immunological response and cytokine release those results in TMEP after HZ.