Birth and coming of age of islet autoantibodies

Author:

Bonifacio E12ORCID,Achenbach P34

Affiliation:

1. DFG Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany

2. Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, Dresden, Germany

3. Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany

4. School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Abstract

Summary This review takes the reader through 45 years of islet autoantibody research, from the discovery of islet-cell antibodies in 1974 to today’s population-based screening for presymptomatic early-stage type 1 diabetes. The review emphasizes the current practical value of, and factors to be considered in, the measurement of islet autoantibodies.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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