<scp>HLA</scp> alleles associated to susceptibility to gliptin‐associated bullous pemphigoid in Italian patients-Reference-Cited by-同舟云学术

HLA alleles associated to susceptibility to gliptin‐associated bullous pemphigoid in Italian patients

Published:2024-08 Issue:2 Volume:104 Page:
ISSN:2059-2302
Container-title:HLA
language:en
Short-container-title:HLA

Author:

Andreani Marco¹^ORCID,Mariotti Feliciana²,Pira Anna²,Locatelli Franco³⁴,Testa Giuseppe¹,Battarra Mariarosa¹^ORCID,Caputi Priscilla²,Scarabello Alessandra⁵,Bellei Barbara⁶^ORCID,Campli Cristiana Di⁷,Collina Maria Chiara⁷,Esposito Ilaria⁸,Giampetruzzi Anna Rita⁹,Didona Biagio¹⁰,Pitocco Dario³¹¹,Simone Clara De³⁸,Zenzo Giovanni Di²

Affiliation:

1. Laboratorio di Immunogenetica dei Trapianti IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy

2. Molecular and Cell Biology Laboratory Istituto Dermopatico dell'Immacolata (IDI)‐IRCCS Rome Italy

3. Università Cattolica del Sacro Cuore Rome Italy

4. Dipartimento di Onco‐Ematologia e Terapia Cellulare e Genica IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy

5. Dermatology Unit National Institute for Infectious Diseases IRCCS ‐ L. Spallanzani Rome Italy

6. Laboratory of Cutaneous Physiopathology and Integrated Center for Metabolomics Research San Gallicano Dermatological Institute, IRCCS Rome Italy

7. Department of Vascular Surgery Limb Salvage and Diabetic Foot, IDI‐IRCCS Rome Italy

8. Institute of Dermatology Fondazione Policlinico Universitario A. Gemelli‐IRCCS Rome Italy

9. Dermatology Clinic IDI‐IRCCS Rome Italy

10. Rare Diseases Unit Istituto Dermopatico dell'Immacolata (IDI)‐IRCCS Rome Italy

11. Diabetology Unit Fondazione Policlinico Universitario A. Gemelli‐IRCCS Rome Italy

Abstract

Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin‐associated BP (GABP) patients. A significant association between HLA‐DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.

Funder

Ministero della Salute

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/tan.15616

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