Machine‐learning‐derived heart and brain age are independently associated with cognition-Reference-Cited by-同舟云学术

Machine‐learning‐derived heart and brain age are independently associated with cognition

Published:2023-06-12 Issue:9 Volume:30 Page:2611-2619
ISSN:1351-5101
Container-title:European Journal of Neurology
language:en
Short-container-title:Euro J of Neurology

Author:

Iakunchykova Olena¹^ORCID,Schirmer Henrik²³,Vangberg Torgil⁴⁵,Wang Yunpeng¹,Benavente Ernest D.⁶,van Es René⁷,van de Leur Rutger R.⁷,Lindekleiv Haakon⁸⁹,Attia Zachi I.¹⁰,Lopez‐Jimenez Francisco¹⁰,Leon David A.¹¹,Wilsgaard Tom⁹

Affiliation:

1. Center for Lifespan Changes in Brain and Cognition, Department of Psychology University of Oslo Oslo Norway

2. Akershus University Hospital Lørenskog Norway

3. Institute of Clinical Medicine, Campus Ahus, University of Oslo Oslo Norway

4. Department of Clinical Medicine UiT The Arctic University of Norway Tromsø Norway

5. PET Imaging Center University Hospital of North Norway Tromsø Norway

6. Department of Experimental Cardiology University Medical Center Utrecht The Netherlands

7. Department of Cardiology University Medical Center Utrecht The Netherlands

8. University Hospital of North Norway Tromsø Norway

9. Department of Community Medicine UiT The Arctic University of Norway Tromsø Norway

10. Mayo Clinic College of Medicine Rochester Minnesota USA

11. Department of Noncommunicable Disease Epidemiology London School of Hygiene and Tropical Medicine London UK

Abstract

AbstractBackground and purposeA heart age biomarker has been developed using deep neural networks applied to electrocardiograms. Whether this biomarker is associated with cognitive function was investigated.MethodsUsing 12‐lead electrocardiograms, heart age was estimated for a population‐based sample (N = 7779, age 40–85 years, 45.3% men). Associations between heart delta age (HDA) and cognitive test scores were studied adjusted for cardiovascular risk factors. In addition, the relationship between HDA, brain delta age (BDA) and cognitive test scores was investigated in mediation analysis.ResultsSignificant associations between HDA and the Word test, Digit Symbol Coding Test and tapping test scores were found. HDA was correlated with BDA (Pearson's r = 0.12, p = 0.0001). Moreover, 13% (95% confidence interval 3–36) of the HDA effect on the tapping test score was mediated through BDA.DiscussionHeart delta age, representing the cumulative effects of life‐long exposures, was associated with brain age. HDA was associated with cognitive function that was minimally explained through BDA.

Funder

Helse Nord RHF

Universitetet i Tromsø

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.15902

Reference43 articles.

1. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

2. The long road to a cure for Alzheimer’s disease is paved with failures

3. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

4. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

5. The neuropathology of probable Alzheimer disease and mild cognitive impairment

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