Mapping the Ethics of Translational Genomics: Situating Return of Results and Navigating the Research-Clinical Divide

Author:

Wolf Susan M.,Burke Wylie,Koenig Barbara A.

Abstract

Research on the use of genome and exome sequencing for diagnosis, identification of potential therapies, precision prescribing of pharmaceuticals, and identification of disease risk is progressing rapidly. Research projects now commonly yield findings of potential health importance for the individuals sequenced as well as their relatives, raising difficult questions about investigator responsibilities to offer those research findings for potential clinical work-up. As sequencing is moving into clinical application, the ethical questions are further multiplying. The ethical quandaries will only proliferate as use of sequencing in screening to achieve public health goals is debated more widely.

Publisher

Cambridge University Press (CUP)

Subject

Health Policy,General Medicine,Issues, ethics and legal aspects

Reference80 articles.

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4. Horizon scanning for translational genomic research beyond bench to bedside

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