Protracted <scp>COVID</scp>‐19 pneumonitis early <scp>post‐ABO</scp> incompatible kidney transplantation: Management considerations and the role of whole genome sequencing-Reference-Cited by-同舟云学术

Protracted COVID‐19 pneumonitis early post‐ABO incompatible kidney transplantation: Management considerations and the role of whole genome sequencing

Published:2023-08-27 Issue:11 Volume:28 Page:639-643
ISSN:1320-5358
Container-title:Nephrology
language:en
Short-container-title:Nephrology

Author:

Stoler Sara¹,van Hal Sebastiaan J.²³,Chadban Steve¹³⁴,Le Thomas²,Torzillo Paul³⁵,Scarlato Rose‐Marie¹,Wyburn Kate¹³⁴,Perkins Griffith B.⁶⁷⁸,Marinelli Tina²^ORCID

Affiliation:

1. Department of Renal Medicine Royal Prince Alfred Hospital Sydney New South Wales Australia

2. Department of Infectious Diseases and Microbiology Royal Prince Alfred Sydney New South Wales Australia

3. Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia

4. Kidney Node, Charles Perkins Centre University of Sydney Sydney New South Wales Australia

5. Department of Respiratory Medicine Royal Prince Alfred Hospital Sydney New South Wales Australia

6. Central and Northern Adelaide Renal and Transplantation Service Royal Adelaide Hospital Adelaide South Australia Australia

7. Adelaide Medical School University of Adelaide Adelaide South Australia Australia

8. Immunology Directorate, SA Pathology Adelaide South Australia Australia

Abstract

AbstractWe present the case of a recent ABO incompatible kidney transplant recipient with persistent SARS‐CoV‐2 infection and pneumonitis. Serial whole genome sequencing confirmed intra‐host viral evolution, which was used as a surrogate to confirm active viral replication and support re‐treatment with antivirals, late in the course of infection. A prolonged course of remdesivir combined with immunosuppression modulation resulted in successful clearance of virus and clinical improvement. The diagnostic process undertaken in this case provides a useful guide for other clinicians when approaching similar patients.

Publisher

Wiley

Subject

Nephrology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/nep.14235

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