Sodium‐glucose co‐transporter‐2 inhibitors and the risk of urosepsis: A multi‐site, prevalent new‐user cohort study

Author:

Fisher Anat1,Fralick Michael23ORCID,Filion Kristian B.45ORCID,Dell'Aniello Sophie5,Douros Antonios456ORCID,Tremblay Éric7,Shah Baiju R.389,Ronksley Paul E.10,Alessi‐Severini Silvia1112,Hu Nianping13,Bugden Shawn C.1114,Ernst Pierre515,Lix Lisa M.16ORCID,

Affiliation:

1. Department of Anesthesiology, Pharmacology and TherapeuticsUniversity of British Columbia Vancouver British Columbia Canada

2. Sinai Health System Toronto Ontario Canada

3. Department of MedicineUniversity of Toronto Toronto Ontario Canada

4. Departments of Medicine and Epidemiology, Biostatistics and Occupational HealthMcGill University Montreal Québec Canada

5. Centre for Clinical EpidemiologyLady Davis Institute Montreal Québec Canada

6. Institute of Clinical Pharmacology and Toxicology, Charité‐Universitätsmedizin Berlin Berlin Germany

7. Institut National d'Excellence en Santé et en Services Sociaux (INESSS) Quebec City Quebec Canada

8. ICES Toronto Ontario Canada

9. Department of MedicineDivision of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre Toronto Ontario Canada

10. Department of Community Health Sciences, Cumming School of MedicineUniversity of Calgary Calgary Alberta Canada

11. College of Pharmacy, Rady Faculty of Health SciencesUniversity of Manitoba Winnipeg Manitoba Canada

12. Manitoba Centre for Health Policy, Rady Faculty of Health SciencesUniversity of Manitoba Winnipeg Manitoba Canada

13. The Health Quality Council Saskatoon Saskatchewan Canada

14. School of PharmacyMemorial University of Newfoundland St John's Newfoundland and Labrador Canada

15. Department of MedicineMcGill University Montreal Quebec Canada

16. Department of Community Health SciencesUniversity of Manitoba Winnipeg Manitoba Canada

Funder

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference40 articles.

1. U.S. Food and Drug Administration (FDA). FDA drug safety communication: FDA revises labels of SGLT2 inhibitors for diabetes to include warnings about too much acid in the blood and serious urinary tract infections. Available athttp://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-revises-labels-sglt2-inhibitors-diabetes-include-warnings-about. Accessed December 3 2019.

2. U.S. Food and Drug Administration (FDA). FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes. Available athttp://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-rare-occurrences-serious-infection-genital-area-sglt2-inhibitors-diabetes. Accessed December 3 2019.

3. An update on SGLT2 inhibitors for the treatment of diabetes mellitus;Hsia DS;Curr Opin Endocrinol Diabetes Obes.,2017

4. U.S. Food and Drug Administration (FDA). Questions and answers on FDA's adverse event reporting system (FAERS). Available athttp://www.fda.gov/drugs/surveillance/questions-and-answers-fdas-adverse-event-reporting-system-faers. Accessed January 3 2020.

5. Sodium–Glucose Cotransporter 2 Inhibitors for Type 2 Diabetes

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