Affiliation:
1. Department of Occupational Health and Toxicology, Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health School of Public Health Jiangxi Medical College Nanchang University Nanchang P. R. China
2. Department of Histology and Embryology School of Basic Medical Sciences Jiangxi Medical College Nanchang University Nanchang P. R. China
Abstract
AbstractBackgroundPhysical, chemical, and biological factors in the environment constantly influence in vivo and in vitro biological processes, including diverse histone modifications involved in cancer and metabolism. However, the intricate mechanisms of acetylation regulation remain poorly elucidated. In mammalian spermatogenesis, acetylation plays a crucial role in repairing double‐strand DNA breaks, regulating gene transcription, and modulating various signaling pathways.ResultsThis review summarizes the histone acetylation sites in the mouse testis and provides a comprehensive overview of how histone acetylation is involved in different stages of spermatogenesis under the regulation by histone deacetylases. The regulatory functions of various class histone deacetylases during spermatogenesis and the crossroad between histone acetylation and other histone modifications are highlighted. It is imperative to understand the mechanisms of histone acetylation regulated by histone deacetylases in spermatogenesis, which facilitates to prevent and treat infertility‐related diseases.
Funder
National Natural Science Foundation of China