Model informed dosing of hydroxycholoroquine in COVID‐19 patients: Learnings from the recent experience, remaining uncertainties and gaps

Author:

Thémans Pauline1,Dauby Nicolas23ORCID,Schrooyen Loïc2,Lebout Faustine2,Delforge Marc2,Nasreddine Rakan2,Libois Agnès2,Payen Marie‐Christine2,Konopnicki Déborah2,Wuillaume Francoise4,Lescrainier Cecile4,Verlinden Veerle4,Dogné Jean‐Michel45,Hamdani Jamila4,Musuamba Flora T.46ORCID

Affiliation:

1. Namur Institute for Complex System (naXys) and Department of Mathematics University of Namur Namur Belgium

2. Department of Infectious Diseases Centre Hospitalier Saint‐Pierre, Université Libre de Bruxelles (ULB) Brussels Belgium

3. Environmental Health Research Centre Public Health School, Université Libre de Bruxelles (ULB) Brussels Belgium

4. Belgian Federal Agency for Medicines and Health Products Brussels Belgium

5. Namur Thrombosis and Hemostasis Center, Department of Pharmacy University of Namur Namur Belgium

6. Faculty of Pharmaceutical Sciences University of Lubumbashi Lubumbashi DR Congo

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

1. https://coronavirus.jhu.edu/map.html

2. Pharmacokinetics of Hydroxychloroquine and Its Clinical Implications in Chemoprophylaxis against Malaria Caused by Plasmodium vivax

3. Population Pharmacokinetics of Hydroxychloroquine in Patients With Rheumatoid Arthritis

4. Population Pharmacokinetics of Hydroxychloroquine in Japanese Patients With Cutaneous or Systemic Lupus Erythematosus

5. In vitro antiviral activity and projection of optimized dosing Design of Hydroxychloroquine for the treatment of severe acute respiratory syndrome;Yao X;Clin Infect Dis,2020

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