Affiliation:
1. Department of Manufacturing Pharmacy, College of Pharmacy Rangsit University Pathum Thani Thailand
2. Faculty of Pharmacy Silpakorn University Nakhon Pathom Thailand
3. Faculty of Pharmaceutical Sciences Burapha University Chonburi Thailand
4. Academy of Science The Royal Society of Thailand Bangkok Thailand
5. Centre for Transdisciplinary Research, Department of Pharmacology Saveetha Dental College and Hospitals, Saveetha University Chennai India
Abstract
AbstractObjectiveThe excessive use of plastic packaging, even though it is possible to recycle it, is one of the main causes of global warming. In this study, dissolvable shower gel tablets for multiple uses have been developed in order to reduce the use of fresh plastic packaging.MethodsThe appropriate ratio of two surfactants, cocoyl glutamic acid (CGA) and sodium coco sulphate (SCS), was optimized using design of experiments. Additionally, skin hydration of the emollient either omega oil or glycerine was taken into account when determining its concentration. After that, powdered shower gel formulations were made and tested for their properties, including cleaning power, and foamability. On 30 human volunteers, the effects of reconstituted shower gel on skin redness, cleaning effectiveness and overall satisfaction were evaluated.ResultsThe study found that, when cleaning power and foam height were taken into account, the proper surfactant ratio was 7.5:0 (SCS:CGA). The 5% glycerine shower gel formula demonstrated significantly greater skin hydration than other formulas. The in vivo study's findings demonstrated that there was no statistically significant difference between selected formulas (5% glycerine and 2.5% omega oil) in terms of cleaning ability. Comparing both formulas to the control, neither showed any skin redness. Additionally, it was discovered that the developed products were much more effective at cleaning and easier to use when washing for the volunteers than regular liquid soap. Overall satisfaction and the moisturizing feel were not significantly different among all products.ConclusionThe formula with 7.5% SCS and 5% glycerine is said to be the best one for both cleaning ability and moisturizing effect. These findings suggest that dissolvable shower gel tablets with enhanced skin benefits could offer a promising innovation in the personal care industry.
Funder
National Research Council of Thailand
Silpakorn University
Subject
Colloid and Surface Chemistry,Dermatology,Drug Discovery,Pharmaceutical Science,Aging,Chemistry (miscellaneous)