Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells
Author:
Affiliation:
1. Graduate School of Pharmaceutical Sciences; Tohoku University; Sendai Japan
2. Faculty of Life Sciences; Kumamoto University; Kumamoto Japan
3. Japan Agency for Medical Research and Development (AMED) CREST; Tokyo Japan
Funder
Japan Society for the Promotion of Science
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jnc.13960/fullpdf
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3. Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier;Bauer;Mol Pharmacol,2007
4. Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain;Cannon;Proc. Natl Acad. Sci. USA,2012
5. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases;Chen;FEBS J.,2011
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