Congenital cytomegalovirus and pulmonary hypertension

Author:

Alkoby‐Meshulam Layah1ORCID,Amir Jacob12,Lubin Daniel3,Klinger Gil24,Guttesman Giora25,Zangen Samuel6,Bilavsky Efraim12

Affiliation:

1. Department of Pediatrics C Schneider Children's Medical Center Petah Tiqva Israel

2. Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

3. Department of Neonatal Intensive Care Mayanei Hayeshua Medical Center Bnei Brak Israel

4. Department of Neonatal Intensive Care Schneider Children's Medical Center Petah Tiqva Israel

5. Department of Pediatrics Meir Medical Center Kfar Saba Israel

6. Department of Neonatal Intensive Care Barzilai Medical Center Ashkelon Israel

Abstract

AbstractLung involvement in children with congenital cytomegalovirus infection has been scarcely described. We describe three new cases of persistent pulmonary hypertension in children with congenital cytomegalovirus and review the other seven cases reported in the literature since 1988. All children had a symptomatic infection, including severe central nervous system or visceral findings. Morbidity and mortality were high. Persistent pulmonary hypertension may be a rare complication in severely symptomatic congenital cytomegalovirus infants. It is important to screen for congenital cytomegalovirus in cases of idiopathic refractory persistent pulmonary hypertension. Intensive treatment should be undertaken to treat this potentially rare lung involvement in combination with antiviral treatment.

Publisher

Wiley

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