Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9-Reference-Cited by-同舟云学术

Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9

Published:1996-11 Issue:3 Volume:241 Page:797-804
ISSN:0014-2956
Container-title:European Journal of Biochemistry
language:en
Short-container-title:Eur J Biochem

Author:

Jean Pascale,Lopez-Garcia Pilar,Dansette Patrick,Mansuy Daniel,Goldstein Joyce L.

Publisher

Wiley

Subject

Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1432-1033.1996.00797.x/fullpdf

Reference33 articles.

1. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

2. Chimeras of the Human Cytochrome P450 1A Family Produced in Yeast. Accumulation in Microsomal Membranes, Enzyme Kinetics and Stability

3. Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

4. M. A. Correia, and P. O. R. Montellano (1995 ) inCytochrome P450, structure, mechanism and biochemistry (pp. 607 -630 , Plenum Press, New York.

5. Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes

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