Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor
Author:
Publisher
Wiley
Subject
Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1432-1033.1994.tb18983.x/fullpdf
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1. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
2. Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells
3. Characterization of an endogenous substrate of the insulin receptor in cultured cells.
4. Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.
5. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.
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