Role of α-gal epitope/anti-Gal antibody reaction in immunotherapy and its clinical application in pancreatic cancer

Author:

Tanemura Masahiro,Miyoshi Eiji1,Nagano Hiroaki2,Eguchi Hidetoshi2,Taniyama Kiyomi3,Kamiike Wataru3,Mori Masaki2,Doki Yuichiro2

Affiliation:

1. Department of Molecular Biochemistry and Clinical Investigation; Osaka University Graduate School of Medicine; Osaka; Japan

2. Department of Gastroenterological Surgery; Osaka University Graduate School of Medicine; Osaka; Japan

3. Department of Surgery and Institute for Clinical Research; National Hospital Organization Kure Medical Center and Chugoku Cancer Center; Hiroshima; Japan

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference51 articles.

1. Cancer statistics, 2010;Jemal;CA Cancer J Clin,2011

2. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors;Lepisto;Cancer Ther,2008

3. The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy;Galili;Immunol Cell Biol,2005

4. The Galalpha1, 3Galbeta1, 4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance;Macher;Biochim Biophys Acta,2008

5. Intratumoral injection of alpha-gal glycolipids induces xenograft-like destruction and conversion of lesions into endogenous vaccines;Galili;J Immunol,2007

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