Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity

Author:

Stoop Esther J. M.1,Mishra Arun K.2,Driessen Nicole N.1,van Stempvoort Gunny1,Bouchier Pascale1,Verboom Theo1,van Leeuwen Lisanne M.1,Sparrius Marion1,Raadsen Susanne A.1,van Zon Maaike3,van der Wel Nicole N.3,Besra Gurdyal S.4,Geurtsen Jeroen1,Bitter Wilbert15,Appelmelk Ben J.1,van der Sar Astrid M.1

Affiliation:

1. Department of Medical Microbiology and Infection Control; VU University Medical Center; van der Boechorststraat 7 1081 BT Amsterdam The Netherlands

2. Mycobacterial Research Division; National Institute for Medical Research; The Ridgeway Mill Hill London NW7 1AA UK

3. Division of Cell Biology-B6; Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL); 1066 CS Amsterdam The Netherlands

4. School of Biosciences; University of Birmingham; Edgbaston Birmingham B15 2TT UK

5. Department of Molecular Microbiology; VU University; de Boelelaan 1085 1081 HV Amsterdam The Netherlands

Funder

Wellcome Trust

Publisher

Hindawi Limited

Subject

Virology,Immunology,Microbiology

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