β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells

Author:

Avrahami Dana1,Wang Yue J.2,Klochendler Agnes3,Dor Yuval3,Glaser Benjamin1,Kaestner Klaus H.2ORCID

Affiliation:

1. Endocrinology and Metabolism Service, Department of Internal Medicine; Hadassah-Hebrew University Medical Center; Jerusalem Israel

2. Department of Genetics and Institute for Diabetes, Obesity, and Metabolism; Perelman School of Medicine, University of Pennsylvania; Philadelphia Pennsylvania

3. Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada; The Hebrew University-Hadassah Medical School; Jerusalem Israel

Funder

National Institutes of Health

BIRAX Regenerative Medicine Initiative

Israel Science Foundation

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference40 articles.

1. Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells;Salomon;Exp Cell Res,1986

2. Actively synthesizing beta-cells secrete preferentially after glucose stimulation;Bosco;Endocrinology,1991

3. Physiologic relevance of heterogeneity in the pancreatic beta-cell population;Pipeleers;Diabetologia,1994

4. Pancreatic beta cell heterogeneity in glucose-induced insulin secretion;Van Schravendijk;J Biol Chem,1992

5. Heterogeneity in pancreatic beta-cell population;Pipeleers;Diabetes,1992

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