Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state

Author:

Narita Minoru,Imai Satoshi,Nakamura Atsushi,Ozeki Ayumi,Asato Megumi,Rahmadi Mahardian,Sudo Yuka,Hojo Minoru,Uezono Yasuhito,Devi Lakshmi A.,Kuzumaki Naoko,Suzuki Tsutomu

Publisher

Wiley

Subject

Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)

Reference22 articles.

1. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence;Bohn;Nature,2000

2. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins;Claing;Prog Neurobiol,2002

3. Desensitization of G protein-coupled receptors and neuronal functions;Gainetdinov;Annu Rev Neurosci,2004

4. Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons;Haberstock-Debic;J Neurosci,2005

5. Differences in tolerance to anti-hyperalgesic effects between chronic treatment with morphine and fentanyl under a state of pain;Imai;Nihon Shinkei Seishin Yakurigaku Zasshi,2006

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