AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner

Author:

Keenan C M12,Storr M A234,Thakur G A5,Wood J T5,Wager-Miller J6,Straiker A6,Eno M R5,Nikas S P5,Bashashati M12,Hu H17,Mackie K6,Makriyannis A5,Sharkey K A12

Affiliation:

1. Hotchkiss Brain Institute; Department of Physiology and Pharmacology; Cumming School of Medicine; University of Calgary; Alberta Canada

2. Snyder Institute for Chronic Diseases; Cumming School of Medicine; University of Calgary; Alberta Canada

3. Division of Gastroenterology; Department of Medicine; Cumming School of Medicine; University of Calgary; Alberta Canada

4. Department of Medicine; Ludwig-Maximilians University; Munich Germany

5. Center for Drug Discovery; Northeastern University; Boston MA USA

6. Department of Psychological and Brain Sciences; Gill Center for Biomolecular Science; Indiana University; Bloomington IN USA

7. Division of Gastroenterology; Department of Internal Medicine; Kaohsiung Medical University Hospital; Kaohsiung Medical University; Kaohsiung Taiwan

Funder

National Institutes of Health

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Pharmacology

Reference66 articles.

1. The gastrointestinal pharmacology of cannabinoids: focus on motility;Abalo;Pharmacology,2012

2. Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain;Adam;Bioorg Med Chem Lett,2012

3. The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors;Alexander;Br J Pharmacol,2013

4. Cannabinoids and gastrointestinal motility: animal and human studies;Aviello;Eur Rev Med Pharmacol Sci,2008

5. Interaction between cannabinoid CB1 receptors and endogenous ATP in the control of spontaneous mechanical activity in mouse ileum;Baldassano;Br J Pharmacol,2009

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