Reciprocal abrogation of <scp>PKM</scp> isoforms: contradictory outcomes and differing impact of splicing signal on <scp>CRISPR</scp> /Cas9 mediates gene editing in keratinocytes-Reference-Cited by-同舟云学术

Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR /Cas9 mediates gene editing in keratinocytes

Published:2022-09-24 Issue:9 Volume:290 Page:2338-2365
ISSN:1742-464X
Container-title:The FEBS Journal
language:en
Short-container-title:The FEBS Journal

Author:

Nold Simon P.¹,Sych Khrystyna¹,Imre Gergely¹,Fuhrmann Dominik C.²,Pfeilschifter Josef¹,Vutukuri Rajkumar¹^ORCID,Schnutgen Frank³⁴⁵,Wittig Ilka⁶⁷,Meisterknecht Jana⁶⁷,Frank Stefan¹,Goren Itamar¹^ORCID

Affiliation:

1. Pharmazentrum Frankfurt/ZAFES, General Pharmacology and Toxicology, Faculty of Medicine Goethe University Frankfurt Germany

2. Faculty of Medicine, Institute of Biochemistry I Goethe University Frankfurt Germany

3. Hematology/Oncology, Faculty of Medicine 2, University Hospital Goethe University Frankfurt Germany

4. German Cancer Research Center and German Cancer Consortium Heidelberg Germany

5. Frankfurt Cancer Institute (FCI) Germany

6. Functional Proteomics, Institute of Cardiovascular Physiology Goethe University Frankfurt Germany

7. German Centre for Cardiovascular Research (DZHK), Partner Site Rhein‐Main Frankfurt Germany

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/febs.16625

Reference74 articles.

1. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.

2. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

3. Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

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